Doubling Down on Mutant RAS Can MEK or Break Leukemia
نویسندگان
چکیده
Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive biomarker.
منابع مشابه
MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations
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ورودعنوان ژورنال:
- Cell
دوره 168 شماره
صفحات -
تاریخ انتشار 2017